home *** CD-ROM | disk | FTP | other *** search
- These include:
- • Nearly universal sterility in males and infertility and premature menopause in women over age 25 who receive
- the equivalent of six cycles of MOPP. These effects appear to be largely irreversible. But children born to
- parents treated for Hodgkin's disease by any of the standard treatments have had normal birth weights and no
- increased incidence of birth defects.
- • MOPP is also associated with an increased risk—between 1 and 5 percent— of acute leukemia, which is most
- common about four years after treatment and is no longer appreciated by 10 years. The risk of leukemia may
- be increased by the use of MOPP after splenectomy.
- • Non-Hodgkin's lymphomas are increased in HD patients treated by any method.
- • Patients receiving radiotherapy are at increased risk of developing a second malignancy in the irradiated tissues,
- particularly skin cancer, breast cancer, stomach cancer, soft tissue and bone cancer and lung cancer. Any
- patient who is irradiated would be very wise to stop smoking, since the incidence of lung cancer is strongly
- related to tobacco use.
- • There are theoretical concerns with the use of ABVD in that bleomycin may be toxic to the lungs and
- doxorubicin is associated with cardiac toxicity. Both of these effects depend on the dose used and are also
- affected by the combined use of radiotherapy.
-
